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mor cre  (Jackson Laboratory)

 
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    Jackson Laboratory mor cre
    A. Schematic depicting experimental design. SCN slices were prepared from 7-8-month-old <t>MOR-Cre;Ai32</t> mice of both sexes. B. Light stimulation of MOR input has no significant effect on firing rate when all neurons were combined together (p < 0.05 by Friedman Repeated Measures Analysis of Variance on Ranks, n = 13/7). C. Pie chart showing differential responses of SCN neurons to light stimulation. Out of all neurons recorded, the majority showed an increase of greater than 10% during light stimulation (n = 13,7). D. Light stimulation induced a significant increase in firing in a subset of SCN neurons, n = 6/3. E. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible excitation when MOR input was optogenetically activated. F. A smaller subset of SCN neurons was reversibly inhibited by light stimulation, n = 3/3. G. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible inhibition when MOR input was optogenetically activated. H. Sample image of MOR+ fibers and neurons in the SCN and surrounding area. Image taken from an MOR-Cre;Ai14 mouse, inset scale bar: 10µm. I. Proposed neurocircuit of converging glutamatergic and GABAergic MOR+ input to the SCN.
    Mor Cre, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mor+cre/bio_rxiv__64898__2026__04__30__721903-37-1-8?v=Jackson+Laboratory
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    1) Product Images from "Alcohol and Opioids Modulate Excitatory Inputs to the SCN"

    Article Title: Alcohol and Opioids Modulate Excitatory Inputs to the SCN

    Journal: bioRxiv

    doi: 10.64898/2026.04.30.721903

    A. Schematic depicting experimental design. SCN slices were prepared from 7-8-month-old MOR-Cre;Ai32 mice of both sexes. B. Light stimulation of MOR input has no significant effect on firing rate when all neurons were combined together (p < 0.05 by Friedman Repeated Measures Analysis of Variance on Ranks, n = 13/7). C. Pie chart showing differential responses of SCN neurons to light stimulation. Out of all neurons recorded, the majority showed an increase of greater than 10% during light stimulation (n = 13,7). D. Light stimulation induced a significant increase in firing in a subset of SCN neurons, n = 6/3. E. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible excitation when MOR input was optogenetically activated. F. A smaller subset of SCN neurons was reversibly inhibited by light stimulation, n = 3/3. G. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible inhibition when MOR input was optogenetically activated. H. Sample image of MOR+ fibers and neurons in the SCN and surrounding area. Image taken from an MOR-Cre;Ai14 mouse, inset scale bar: 10µm. I. Proposed neurocircuit of converging glutamatergic and GABAergic MOR+ input to the SCN.
    Figure Legend Snippet: A. Schematic depicting experimental design. SCN slices were prepared from 7-8-month-old MOR-Cre;Ai32 mice of both sexes. B. Light stimulation of MOR input has no significant effect on firing rate when all neurons were combined together (p < 0.05 by Friedman Repeated Measures Analysis of Variance on Ranks, n = 13/7). C. Pie chart showing differential responses of SCN neurons to light stimulation. Out of all neurons recorded, the majority showed an increase of greater than 10% during light stimulation (n = 13,7). D. Light stimulation induced a significant increase in firing in a subset of SCN neurons, n = 6/3. E. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible excitation when MOR input was optogenetically activated. F. A smaller subset of SCN neurons was reversibly inhibited by light stimulation, n = 3/3. G. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible inhibition when MOR input was optogenetically activated. H. Sample image of MOR+ fibers and neurons in the SCN and surrounding area. Image taken from an MOR-Cre;Ai14 mouse, inset scale bar: 10µm. I. Proposed neurocircuit of converging glutamatergic and GABAergic MOR+ input to the SCN.

    Techniques Used: Inhibition

    A. Schematic depicting experimental design. SCN slices were prepared from MOR-Cre;Ai32 mice of both sexes. B. Sample trace of an optically induced EPSC (oEPSC) in an SCN neuron, showing ∼5 ms latency. C. Bath application of AMPAR antagonist NBQX (20 µM) reduced oEPSC amplitude in an SCN neuron. D. Sample trace of a recorded neuron showing the baseline (BL), the response during NBQX application, and the subtraction of the baseline and NBQX response to equal the actual oEPSC response. E. The MOR agonist DAMGO reduced the amplitude of oEPSCs following MOR stimulation. F. Schematic depicting experimental design. SCN slices were prepared from VGlut2-Cre;Ai32 mice of both sexes. G. Time course showing bath application of fentanyl (1 µM) acutely and persistently suppresses glutamatergic input to SCN neurons. H. Fentanyl bath application significantly reduced the firing rate of oEPSCs compared to baseline (BL). This effect persisted throughout the washout (wash) period (***p < 0.001 by one-way RM ANOVA, n = 6/4).
    Figure Legend Snippet: A. Schematic depicting experimental design. SCN slices were prepared from MOR-Cre;Ai32 mice of both sexes. B. Sample trace of an optically induced EPSC (oEPSC) in an SCN neuron, showing ∼5 ms latency. C. Bath application of AMPAR antagonist NBQX (20 µM) reduced oEPSC amplitude in an SCN neuron. D. Sample trace of a recorded neuron showing the baseline (BL), the response during NBQX application, and the subtraction of the baseline and NBQX response to equal the actual oEPSC response. E. The MOR agonist DAMGO reduced the amplitude of oEPSCs following MOR stimulation. F. Schematic depicting experimental design. SCN slices were prepared from VGlut2-Cre;Ai32 mice of both sexes. G. Time course showing bath application of fentanyl (1 µM) acutely and persistently suppresses glutamatergic input to SCN neurons. H. Fentanyl bath application significantly reduced the firing rate of oEPSCs compared to baseline (BL). This effect persisted throughout the washout (wash) period (***p < 0.001 by one-way RM ANOVA, n = 6/4).

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    A. Schematic depicting experimental design. SCN slices were prepared from 7-8-month-old <t>MOR-Cre;Ai32</t> mice of both sexes. B. Light stimulation of MOR input has no significant effect on firing rate when all neurons were combined together (p < 0.05 by Friedman Repeated Measures Analysis of Variance on Ranks, n = 13/7). C. Pie chart showing differential responses of SCN neurons to light stimulation. Out of all neurons recorded, the majority showed an increase of greater than 10% during light stimulation (n = 13,7). D. Light stimulation induced a significant increase in firing in a subset of SCN neurons, n = 6/3. E. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible excitation when MOR input was optogenetically activated. F. A smaller subset of SCN neurons was reversibly inhibited by light stimulation, n = 3/3. G. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible inhibition when MOR input was optogenetically activated. H. Sample image of MOR+ fibers and neurons in the SCN and surrounding area. Image taken from an MOR-Cre;Ai14 mouse, inset scale bar: 10µm. I. Proposed neurocircuit of converging glutamatergic and GABAergic MOR+ input to the SCN.
    Mor Cre, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    A. Schematic depicting experimental design. SCN slices were prepared from 7-8-month-old <t>MOR-Cre;Ai32</t> mice of both sexes. B. Light stimulation of MOR input has no significant effect on firing rate when all neurons were combined together (p < 0.05 by Friedman Repeated Measures Analysis of Variance on Ranks, n = 13/7). C. Pie chart showing differential responses of SCN neurons to light stimulation. Out of all neurons recorded, the majority showed an increase of greater than 10% during light stimulation (n = 13,7). D. Light stimulation induced a significant increase in firing in a subset of SCN neurons, n = 6/3. E. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible excitation when MOR input was optogenetically activated. F. A smaller subset of SCN neurons was reversibly inhibited by light stimulation, n = 3/3. G. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible inhibition when MOR input was optogenetically activated. H. Sample image of MOR+ fibers and neurons in the SCN and surrounding area. Image taken from an MOR-Cre;Ai14 mouse, inset scale bar: 10µm. I. Proposed neurocircuit of converging glutamatergic and GABAergic MOR+ input to the SCN.
    Aavdj Syn Dio Mch 2a Mor, supplied by Addgene inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    A. Schematic depicting experimental design. SCN slices were prepared from 7-8-month-old MOR-Cre;Ai32 mice of both sexes. B. Light stimulation of MOR input has no significant effect on firing rate when all neurons were combined together (p < 0.05 by Friedman Repeated Measures Analysis of Variance on Ranks, n = 13/7). C. Pie chart showing differential responses of SCN neurons to light stimulation. Out of all neurons recorded, the majority showed an increase of greater than 10% during light stimulation (n = 13,7). D. Light stimulation induced a significant increase in firing in a subset of SCN neurons, n = 6/3. E. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible excitation when MOR input was optogenetically activated. F. A smaller subset of SCN neurons was reversibly inhibited by light stimulation, n = 3/3. G. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible inhibition when MOR input was optogenetically activated. H. Sample image of MOR+ fibers and neurons in the SCN and surrounding area. Image taken from an MOR-Cre;Ai14 mouse, inset scale bar: 10µm. I. Proposed neurocircuit of converging glutamatergic and GABAergic MOR+ input to the SCN.

    Journal: bioRxiv

    Article Title: Alcohol and Opioids Modulate Excitatory Inputs to the SCN

    doi: 10.64898/2026.04.30.721903

    Figure Lengend Snippet: A. Schematic depicting experimental design. SCN slices were prepared from 7-8-month-old MOR-Cre;Ai32 mice of both sexes. B. Light stimulation of MOR input has no significant effect on firing rate when all neurons were combined together (p < 0.05 by Friedman Repeated Measures Analysis of Variance on Ranks, n = 13/7). C. Pie chart showing differential responses of SCN neurons to light stimulation. Out of all neurons recorded, the majority showed an increase of greater than 10% during light stimulation (n = 13,7). D. Light stimulation induced a significant increase in firing in a subset of SCN neurons, n = 6/3. E. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible excitation when MOR input was optogenetically activated. F. A smaller subset of SCN neurons was reversibly inhibited by light stimulation, n = 3/3. G. Sample traces of 3 sweeps in an SCN neuron showing repeated, reversible inhibition when MOR input was optogenetically activated. H. Sample image of MOR+ fibers and neurons in the SCN and surrounding area. Image taken from an MOR-Cre;Ai14 mouse, inset scale bar: 10µm. I. Proposed neurocircuit of converging glutamatergic and GABAergic MOR+ input to the SCN.

    Article Snippet: VGlut2-Cre, MOR-Cre, and Ai32 mice were obtained from the Jackson Laboratory.

    Techniques: Inhibition

    A. Schematic depicting experimental design. SCN slices were prepared from MOR-Cre;Ai32 mice of both sexes. B. Sample trace of an optically induced EPSC (oEPSC) in an SCN neuron, showing ∼5 ms latency. C. Bath application of AMPAR antagonist NBQX (20 µM) reduced oEPSC amplitude in an SCN neuron. D. Sample trace of a recorded neuron showing the baseline (BL), the response during NBQX application, and the subtraction of the baseline and NBQX response to equal the actual oEPSC response. E. The MOR agonist DAMGO reduced the amplitude of oEPSCs following MOR stimulation. F. Schematic depicting experimental design. SCN slices were prepared from VGlut2-Cre;Ai32 mice of both sexes. G. Time course showing bath application of fentanyl (1 µM) acutely and persistently suppresses glutamatergic input to SCN neurons. H. Fentanyl bath application significantly reduced the firing rate of oEPSCs compared to baseline (BL). This effect persisted throughout the washout (wash) period (***p < 0.001 by one-way RM ANOVA, n = 6/4).

    Journal: bioRxiv

    Article Title: Alcohol and Opioids Modulate Excitatory Inputs to the SCN

    doi: 10.64898/2026.04.30.721903

    Figure Lengend Snippet: A. Schematic depicting experimental design. SCN slices were prepared from MOR-Cre;Ai32 mice of both sexes. B. Sample trace of an optically induced EPSC (oEPSC) in an SCN neuron, showing ∼5 ms latency. C. Bath application of AMPAR antagonist NBQX (20 µM) reduced oEPSC amplitude in an SCN neuron. D. Sample trace of a recorded neuron showing the baseline (BL), the response during NBQX application, and the subtraction of the baseline and NBQX response to equal the actual oEPSC response. E. The MOR agonist DAMGO reduced the amplitude of oEPSCs following MOR stimulation. F. Schematic depicting experimental design. SCN slices were prepared from VGlut2-Cre;Ai32 mice of both sexes. G. Time course showing bath application of fentanyl (1 µM) acutely and persistently suppresses glutamatergic input to SCN neurons. H. Fentanyl bath application significantly reduced the firing rate of oEPSCs compared to baseline (BL). This effect persisted throughout the washout (wash) period (***p < 0.001 by one-way RM ANOVA, n = 6/4).

    Article Snippet: VGlut2-Cre, MOR-Cre, and Ai32 mice were obtained from the Jackson Laboratory.

    Techniques: